1-Pyrrolidinecarboxylic acid, 2-((2-formyl-1-pyrrolidinyl)carbonyl)-, 1,1-dimethylethyl ester, (S-(R*,R*))-
Prolyl Endopeptidase Inhibitor 1
CAS: 86925-97-5
Molecular Formula: C15H24N2O4
1-Pyrrolidinecarboxylic acid, 2-((2-formyl-1-pyrrolidinyl)carbonyl)-, 1,1-dimethylethyl ester, (S-(R*,R*))- - Names and Identifiers
1-Pyrrolidinecarboxylic acid, 2-((2-formyl-1-pyrrolidinyl)carbonyl)-, 1,1-dimethylethyl ester, (S-(R*,R*))- - Physico-chemical Properties
| Molecular Formula | C15H24N2O4 |
| Molar Mass | 296.36 |
| Density | 1.231±0.06 g/cm3(Predicted) |
| Boling Point | 448.6±45.0 °C(Predicted) |
| Appearance | Solid |
| pKa | -2.42±0.40(Predicted) |
| Storage Condition | 2-8°C，密封，干燥 |
| Sensitive | Light Sensitive |
| In vitro study | Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) strongly inhibits the mammalian prolyl endopeptidase with a K i value of nM order, while the K i value for the microbial enzyme is only of microM order (K i =3.2 μM for Flavobacterium ). |
1-Pyrrolidinecarboxylic acid, 2-((2-formyl-1-pyrrolidinyl)carbonyl)-, 1,1-dimethylethyl ester, (S-(R*,R*))- - Reference Information
| biological activity | Prolyl endoptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent proline Endopeptidase (PEP; PE) Inhibitor, the Ki value was 15 nM. Prolyl endopeptidase-IN-1 has an anti-amnestic effect. |
| Target | Ki: 15 nM |
Last Update：2024-04-09 02:00:14
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